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diagnosis management oncology differential lupus erythematosus signs sle systemic algorithm causes disease physicalexam symptoms table workup chronic classification cll dermatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... infarction, Severe trauma ... Diagnosis #Algorithm #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... Conservative/supportive care ... only curative treatment ... #hematology #oncology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... Autoinflammatory #Somatic #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
• Mechanical Trauma ... ) - HELLP syndrome ... lactam antibiotics are ... differential #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Overview: • Most common ... , smudge cells are ... immunophenotype Clinical ... 5) Symptoms of anemia ... Leukemia #oncology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Renal Failure Treatment ... • Supportive Care ... diagnosis #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... Constitutional Syndromes ... Treatment: ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... necrosis of hip (rare ... Demyelinating syndromes ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
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