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diagnosis hematology causes classification hodgkins lymphoma macrocytic management mds microcytic myelodysplasia myelodysplastic platelets secondary syndromes testing underproduction
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... malignancies • Anemia ... (specifically: iron ... deficiency, hemolysis ... Chronic inflammatory disorders
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... • Rheumatic disorders ... effect following treatment ... malignancy • Iron ... deficiency anemia
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Pancytopenia - Differential ... Diagnosis Algorithm ... LDH, ESR, CRP, iron ... ↑ Destruction (hemolysis ... #hematology #workup
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential ... Acquired Aplastic Anemia ... #Workup #Differential ... #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
- Iron deficiency ... Probable bone marrow disorder ... #hematology #diagnosis ... #differential # ... workup
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential ... Acquired Aplastic Anemia ... #Workup #Differential ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider RBC membrane disorder ... #Anemia #Differential ... #workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
acute blood loss, hemolysis ... erythropoietin (EPO), iron ... (BM) ablative disorders ... substrate (e.g. iron ... #Workup #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... rings of excess iron ... blood count with differential ... #oncology
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