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management differential causes workup anemia summary lupus systemic erythematosus hemophagocytic hepatology lymphohistiocytosis syndrome table thrombocytopenia blood chronic classification coagulation comparison
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... HLH 2. ... Still's disease ... Hyperferritinemia #Algorithm ... #Hematology
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... #differential #diagnosis ... #algorithm #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... lymph node, or liver ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... thrombocytopenia • Liver ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... HLH syndrome 5. ... Metastatic Disease ... #Algorithm #Hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Dermatomyositis Anti-LKM (liver ... #diagnosis #table ... #rheumatology #
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... disorders • Celiac disease ... effect following treatment ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Algorithm Decreased ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... #Algorithm #hematology
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