27 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential Diagnosis ... Algorithm Severe ... • Cholestatic disease ... • Others #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
valproate, azoles), Drugs ... Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... #hepatology #algorithm ... Transaminitis #LFTs
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... • Drugs Matthew ... #differential #diagnosis ... #algorithm #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Algorithm DILI ... /HDS treatments ... disease, Hepatic ... #Algorithm #hepatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Algorithm Low ... Renal Disease, Liver ... Deficiency • Drugs ... #Hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Algorithm ALP ... Highest • Bone • Liver ... Cholestasis - Drugs ... #Algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... - Differential Diagnosis ... 15X ULN - Drugs ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... disease, liver ... Hepatitis (AAH) Drug-Induced ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
- Differential Diagnosis ... Algorithm Thrombocytopenia ... Congenital - Rare • Drugs ... Iatrogenic) • Liver ... #Hematology