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hematology differential oncology gammopathy management mgus significance signs adhesivecapsulitis arthritis chronic classification clinical cll complications disorders frozenshoulder fungal hemeonc infections
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... DADS-M, Sporadic, late-onset ... Ig deposition disease ... (light chain vs ... #hematology #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
corresponding light-chain ... constitutional symptoms ... amyloidosis • Rate ... #Significance #hematology ... #diagnosis #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Algorithm Hodgkin ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... neuropathy) • Systemic late-onset ... • Crystalline: light ... Sneddon-Wilkinson disease ... #Diagnosis #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... → fevers, night ... chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... #hemeonc #diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
treatment of infective symptoms ... deposition disease ... glomerulonephritis, light-chain ... Complications #diagnosis ... #hematology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... Severe, worse at night ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... stages #staging #msk
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... constitutional symptoms ... up with pain at night ... #Differential #Diagnosis ... #MSK #rheumatology
Scoliosis: Pathogenesis and clinical findings (Cobb Angle > 10 Degrees) • Incr Axial rotation of thoracic
Restrictive Pulmonary Disease ... , Right Sided Heart ... #Scoliosis #pathophysiology ... #msk #diagnosis ... #signs #symptoms
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Hyperreflexia develops later ... bouts of HTN Diagnostic ... Bilateral signs and/or symptoms ... MCTD - Bechet disease
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