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differential management oncology monoclonal sle workup arthritis erythematosus signs systemic classification comparison gammopathy joint leukemia pain vasculitis algorithm approach chronic
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... DADS-M, Sporadic, late-onset ... Ig deposition disease ... (light chain vs ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic late-onset ... • Crystalline: light ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... constitutional symptoms ... amyloidosis • Rate ... #Significance #hematology ... #diagnosis #oncology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs #symptoms ... #differential #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
ULN R - Renal disease ... uninvolved serum free light ... (1-2% of MM), light ... #Gammopathies #MGUS ... #diagnosis #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... , Drug-induced Lupus ... , Drug-Induced Lupus ... ANA #patterns #rheumatology ... #diagnosis #differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... permeability Diagnosis ... CNS #neurology #rheumatology ... #cerebritis #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... pain (20%) Renal disease ... Thrombocytopenia #Lupus ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... #differential #diagnosis ... #algorithm #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate ... Differential Diagnosis ... Non-autoimmune rheumatologic ... : • Symptoms limited ... #Rheumatology
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