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rheumatology differential erythematosus lupus systemic symptoms classification joint msk pain vasculitis activation approach autoantibodies chronic cll eularacr fuo leukemia lymphocytic
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... thin smear • Signs ... values supporting hematologic ... UnknownOrigin #workup ... #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... Constitutional domain: Fever ... cutaneous lupus • Arthritis ... #SLE #Systemic ... Erythematosus #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
) General: Fever ... of hip (rare), Arthritis ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... Malar rash 40% - Fever ... involvement 3% SLE-Related ... Lupusreference #SLE ... autoantibodies #signs
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Erythematosus (SLE ... ) - Typical Signs ... Symptoms Alopecia, Fever ... , Arthralgia / arthritis ... #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... noninflammatory Signs ... • Rheumatic fever ... • SLE • Psoriatic ... #MSK #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... erythematosus [SLE ... Histopathologic criteria ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
to Joint Pain - Diagnostic ... acute rheumatic fever ... Chronic = RA, SLE ... #approach #workup ... #differential #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Lymphadenopathy • Fevers ... Physical Exam/Signs ... #workup #oncology ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Coronary arteries - Fever ... Vasculitis: • Fevers ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #
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