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Travel History - Clues to Infectious Disease Diagnosis in a Traveler • Where did you
Infectious Disease Diagnosis ... → Leptospirosis ... Schistosomiasis • Skin ... Rabies, cat scratch fever ... Blood transfusion
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... : Acute blood loss ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... , POEMS • Reaction
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
redness of the skin ... syndrome (SSS) ... and toxic shock syndrome ... or an exposure reaction ... #Diagnosis #Dermatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... disease, recurrent fevers ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... including peripheral blood
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
AIHA, Transfusion reactions ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... - Peripheral Blood ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... Headaches • Pale skin ... result from low blood ... #oncology #hematology ... #diagnosis #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... - Hemolytic anemia ... mountain spotted fever ... • Drug reactions
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
Infections: • Leptospirosis ... No hemolytic anemia ... renal function • Blood ... polymerase-chain-reaction ... a chest film; blood-smear
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... Sjögrens (15%) Skin ... Demyelinating syndromes ... (75%): Anemia ( ... signs #symptoms #diagnosis
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
- Transfusion Reactions ... of high parity blood ... explain symptoms • Fever ... #hematology #diagnosis ... #comparison #table
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