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management differential disease adultonset treatment aosd activation arthritis autoimmune causes clinical cold comparison criteria cutaneous dermatology erythematosus fever fuo hemophagocytic
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Arthralgia/arthritis, Skin ... Differential Diaqnoses ... #Disease #diagnosis ... management #treatment #rheumatology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... weeks - Typical skin ... #AdultOnset #Stills ... Yamaguchi #Criteria #Diagnosis ... #Major #Minor #Rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... , difficult to diagnose ... malignant) to diagnose ... #AdultOnset #Stills ... Disease #AOSD #rheumatology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... Malignancy: - Hematologic ... . autoimmune): Lupus ... , Sarcoidosis, Adult ... onset Still's disease
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... anti-lL6R, anti-ILI #Adult ... #onset #Stills ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Still disease, ... #Rheumatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
population Disease onset ... Insect stings Disease ... , liquids The onset ... Cold #Urticaria #diagnosis ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... diseases: SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis ... treatment #summary #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... Systemic late-onset ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
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