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differential signs management erythematosus lupus sle clinical dermatology autoantibodies classification disease oncology rash scleroderma vasculitis workup adult algorithm ana antibodies
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... thickening Signs and Symptoms ... #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Systemic Sclerosis ... @AnnKumfer #Systemic ... #Sclerosis #Scleroderma ... #diagnosis #signs ... #symptoms #rheumatology
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... anti-Sc170): Diffuse skin ... BCM_InternalMed #Systemic ... #Sclerosis #Autoantibodies ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... sclerosis/polymyositis ... #SLE #Summary #diagnosis ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... Sjögrens (15%) Skin ... joints Nervous system ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... sclerosis/scleroderma ... sclerosis/scleroderma ... ANA #patterns #rheumatology ... #diagnosis #differential
Rheumatologic Review of Systems (ROS): • Fevers • Rashes/photosensitivity • Alopecia • Nail/nailfold abnormalities • Sicca symptoms • Conjunctivitis • Uveitis • Episcleritis • Scleritis • Raynaud's • Oral/genital ulcers • Polychondritis • Enthesitis • Serositis sx • Thomboses • Neuropathy • Pregnancy loss. #Rheumatologic #rheumatology #ROS #ReviewOfSystems #diagnosis #history
of Systems (ROS ... abnormalities • Sicca symptoms ... Episcleritis • Scleritis ... rheumatology #ROS ... ReviewOfSystems #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... malignancies, Multiple sclerosis ... Lupusreference #SLE #Systemic ... autoantibodies #signs #symptoms ... #differential #rheumatology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... with lymphatic system ... Classic - Nodular Sclerosis ... pattern of spread, B symptoms ... pathophysiology #Hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... DADS-M • POEMS (Sclerotic ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... #Differential #Diagnosis
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