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management rheumatology sle syndrome comparison druginduced erythematosus hemophagocytic hepatology hlh lymphohistiocytosis neurology summary systemic table ascorbicacid cerebritis cirrhosis cns coagulation
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... permeability Diagnosis ... #cerebritis #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... Positive in 60-80% of cases ... life-threatening • Treatment ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Discontinuation of causal ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... #diagnosis #management
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... without other cause ... : 33% • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... Drugs, Unknown cause ... Treatment: •
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... renal failure Clinical ... symptoms are not caused ... skin (16-32%): lupus ... anterior/posterior MSK
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... • Infectious causes ... Mycoplasma - Leptospirosis ... Transverse Myelitis Treatment
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... poor nutrition Clinical ... nonimmune hemolysis MSK ... , or any other cause ... vasculitis Treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... constitutional symptoms • Treatment ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
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