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Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes arterial clot ... Hyperhomocysteinemia - Lipoprotein ... Differential #Diagnosis #clots
Lipoprotein Metabolism

Enterocytes release absorbed lipids the form of triglyceride-rich chylomicrons. These are acted upon by endothelial
Lipoprotein Metabolism ... very-low-density lipoproteins ... The low density liproprotein ... #Lipoprotein #Cholesterol
Metabolism of plasma lipoproteins and related genetic diseases - Familial Hypercholesterolemia
Type I (FAMILIAL HYPERCHYLOMICRONEMIA) 
Type IIA
Metabolism of plasma lipoproteins ... pathophysiology #metabolism #lipoproteins
THROMBOELASTOGRAPHY (TEG)
General Principle
• A small cuvette is rotated to simulate sluggish venous flow and stimulate clot
and stimulate clot ... the mass of the clot ... the kinetics of clot ... information about clot ... latency until clot
Therapeutic Plasma Exchange - Circuit Diagram
Goal = removal of abnormal/excess cells or substances that:
 • Have
Cholesterol-containing lipoprotein
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
initiation of fibrin clot ... achieve 20 mm clot ... Maximum strength of clot ... Degradation of clot
Hemothorax - Thoracic ultrasound in trauma
False positive for consolidated lung- organized clot in pleural space after
lung- organized clot ... - Organized clot
Antiphospholipid Syndrome (Hughes' Syndrome) 
Antiphospholipid syndrome - an autoimmune condition where the affected individual produces antibodies
arterial/venous blood clots
REBEL Review 54: Thromboelastogram (TEG) Interpretation

R Time - Time to start forming clot 
K Time -
start forming clot ... Time - Time until clot
Causes of Early (<20 Weeks) and Late Bleeding in Pregnancy  - Differential Diagnosis Algorithm
Early Bleeding
Passing Tissue and Clots ... Passing Tissue and Clots