27 results
Demyelinating Diseases - Differential Diagnosis
 • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE
 •
Demyelinating Diseases ... PML, HTLV-1 • Granulomatous ... : Lymhomatoid granulomatosis ... Demyelinating #Diseases ... Diagnosis #causes #neurology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Manifestations of Granulomatosis ... involvement in granulomatosis ... presentation of the disease ... GPA causes disease ... rash #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
connective tissue disease ... ANCA+ 90% • Granulomatosis ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Skeletal metastatic disease ... disorders, Paget's disease ... VitD: Lymphoma, Granulomatous ... diseases, Idiopathic ... Algorithm #Workup #nephrology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Kawasaki disease ... - Wegener granulomatosis ... and infectious diseases ... - serum disease ... Vessels #Diagnosis #Rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Wegener's granulomatosis ... (TTG) - Celiac disease ... #Associations #diseases ... diagnosis #table #rheumatology
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
Includes granulomatosis ... + antibody) Granulomatosis ... - 80-90% PR3+ Granulomatosis ... PR3 Anti-GBM disease ... PR3 #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Malabsorption • Granulomatous ... disease • ... breast cancer Granulomatous ... anemia) • Systemic granulomatous ... hypogammaglobulinemia #immunology #hematology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Lymphomatoid granulomatosis ... lymphoproliferative disease ... • Metastatic disease ... demyelinating diseases ... causes #radiology #neurology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
VESSEL VASCULITIS (GRANULOMATOUS ... /hr • Biopsy: Granulomatous ... affects the skin, neurologic ... cognitive impairment, neurologic ... Differential #Diagnosis #Rheumatology