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diagnosis erythematosus hematology systemic activation ana anca antibody antineutrophil antinuclear cerebritis classification cns differential diseases hemophagocytic hlh lymphohistiocytosis macrophage mas
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... in drug-induced SLE ... cases • Sjögren syndrome ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease Treatment ... #Systemic #Lupus ... Summary #diagnosis #rheumatology ... #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management ... #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
GBS), systemic lupus ... erythematosus (SLE ... myopathy (IMNM) → Antibodies ... myopathy #diagnosis #management ... #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... hypofunction • Antibodies ... Adenocarcinoma Treatment ... #Rheumatology # ... Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Treatment Approach ... inhibitors, anti-IFN-γ antibodies ... #Hematology #HemeOnc
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... Hypoalbuminemia Treatment ... TAFRO #diagnosis #management ... #rheumatology #
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Anti-Matrilin-1 Ab ○ Antibodies ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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