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diagnosis rheumatology dermatology lupus vasculitis differential erythematosus pathophysiology syndrome systemic behcet chronic cll comparison complications cryoglobulinemia cryoglobulins disease drug eschar
Symptoms Distinguishing Groups of Cutaneous Drug Reactions IgE-mediated reactions: • Onset minutes to hours into treatment course
Symptoms Distinguishing ... Raised off of the skin ... Blistering and/or skin ... #dermatology #clinical ... #comparison #classification
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... inflammation on skin ... pathophysiology #diagnosis #signs ... #symptoms #complications
Scarlet fever • Delayed-type skin reactivity to pyrogenic exotoxin Requires prior exposure • Diffuse erythematous eruption that generally
• Delayed-type skin ... fever #diagnosis #clinical ... #photo #signs # ... symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... Sjögrens (15%) Skin ... erythematosus #signs ... #symptoms #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Pathogenesis and Clinical ... erythematosus (SLE ... ) Signs / Symptoms ... Xeroderma (Dry skin ... #Symptoms
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... vasculitis) • Cutaneous ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Disease Classification ... Seizures • Strokes Skin ... Induced Lupus: • Symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Syndrome: • Clinical ... reticularis & skin ... Henoch-Schönlein purpura) • Cutaneous ... diagnosis #types #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Presentation: Systemic Symptoms ... purpura: Strong sign ... of cutaneous leukocytoclastic ... • Progressive symptoms
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