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diagnosis rheumatology pathophysiology dermatology differential management syndrome lupus manifestations oncology arteritis classification disease erythematosus sjogrens systemic ascorbicacid behcet chronic cll
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Dermatological semiology of Cutaneous ... the context of cutaneous ... disease (10%) : SLE ... dermatology #semiology #signs ... lesions #diagnosis #clinical
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... dermatomyositis, SLE ... leukocytoclastic vasculitis ... dermatology #oncology #clinical ... #skin
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... Presentation - Systemic Symptoms ... purpura: strong sign ... of cutaneous leukocytoclastic ... , and SLE) • Urinalysis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... ) • Cutaneous Lesions ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... erythematosus #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
response -> Subacute cutaneous ... inflammation on skin ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs ... #symptoms #complications
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Presentation: Systemic Symptoms ... purpura: Strong sign ... of cutaneous leukocytoclastic ... • Progressive symptoms
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Syndrome: • Clinical ... reticularis & skin ... Henoch-Schönlein purpura) • Cutaneous ... erythematosus (SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... lymphoproliferative syndrome Clinical ... Seizures • Strokes Skin ... Induced Lupus: • Symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Pathogenesis and Clinical ... response) - Cutaneous ... Pathophysiology #Diagnosis #Signs ... #Symptoms
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