12 results
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... in Hemolytic Anemia ... Anemia #Laboratory #Testing ... #workup #diagnosis ... #hematology #hemolysis
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... hematological Malignancy ... #Workup #Differential ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... hematological Malignancy ... #Workup #Differential ... Diagnosis #Algorithm #Hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Pancytopenia - Differential ... /uL Initial Workup ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology ... #workup
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... aHUS, mechanical cardiac ... valve, vasculitis, malignant ... Diagnosis #Algorithm #workup ... #hematology #testing
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
thromboembolism → Cardiac ... - No other workup ... Hypercoagulable #Workup ... #hematology #diagnosis ... #algorithm #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
concerning for malignancy ... → Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Diagnosis #Algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... ITP, unexplained pancytopenia ... Diagnosis #Causes #Workup ... #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Proximal limb muscle wasting ... of pregnancy, Cardiac ... - gallstone or malignancy ... cholangitis #diagnosis #workup ... #hepatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Febrile Non-Hemolytic ... progresses to pancytopenia ... • Transfusion Cardiac ... false negatives on testing ... diagnosis #management #hematology