58 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Diuretics (e.g. mannitol ... ) 3) Loop Diuretics ... HCTZ) 5) Potassium-sparing ... spironolactone) #Pathophysiology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Osmotic agents (mannitol ... urearetics) 3) Loop ... Adenosine #Nephron #Pathophysiology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
diuretics (e.g. mannitol ... ) 3) Loop diuretic ... Metolazone) 5) Potassium-sparing
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
empagliflozin LOOP ... Chlorthalidone POTASSIUM-SPARING ... DIURETICS • Mannitol
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Extra-renal Losses ... • HTN Absent: Loop ... Differential #Diagnosis #Algorithm ... #causes #potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #pathophysiology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... Piretanide Potassium ... ), Isosorbide, Mannitol ... nephrology #conversion #loop ... #thiazide #classes
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... Differential Diagnosis Algorithm ... Excretion (IV potassium ... Differential #Diagnosis #Algorithm ... #Causes
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Differential Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #high #pathophysiology
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop ... Panel A, loop diuretics ... binding to sodium–potassium–chloride ... #Pathophysiology