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diagnosis hematology causes clinical differential echocardiogram pocus pt abnormal clot dic disseminated intravascular prolonged a4c anticoagulant anticoagulation apixaban artery bleeding
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
presented with acute ... Thrombus in transit ... #Sign #PulmonaryEmbolism ... #Thrombus #Clots ... #InTransit
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 Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... coagulation factors ... drugs e.g. direct thrombin ... intravascular coagulation ... differential #hematology #coagulation
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... aggregation PT, aPTT ... consumption of coagulation ... fibrinogen is also an acute-phase ... Intravascular #Coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... Thrombin, then primes ... #Coagulation #Cascade ... #clot #PT #PTT
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... differential #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... • Prolonged PT/PTT ... • Increased thrombin ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Clot in Transit on POCUS Echocardiogram Not something you ever want to see! How much should clot
Clot in Transit ... should clot in transit ... s4c #cardiology #thrombus ... #VTE #pulmonaryembolism ... #AcutePE
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... • Warfarin • Acute ... pathway to the intrinsic ... Liver disease • Acute ... warfarin, direct thrombin
Pulmonary Artery Clot seen on PSAX in Acute Saddle Pulmonary Embolism - Labeled Thrombus in Purple Suspicious
seen on PSAX in Acute ... Embolism - Labeled Thrombus ... for RV dilation, McConnell's ... The actual thrombus ... #Saddle #PulmonaryEmbolism
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