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diagnosis causes clinical differential echocardiogram pocus pt abnormal aptt cascade clot dic disseminated intravascular models pathophysiology prolonged a4c anticoagulant anticoagulation
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
presented with acute ... Thrombus in transit ... #Sign #PulmonaryEmbolism ... #Thrombus #Clots ... #InTransit
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 The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... Thrombin, then primes ... #Coagulation #Cascade ... diagnosis #models #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... consumption of coagulation ... fibrinogen is also an acute-phase ... Intravascular #Coagulation ... Scoring #diagnosis #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... inhibitors, direct thrombin ... Post-partum • Acute ... catastrophes, Acute ... comparison #diagnosis #hematology
Clot in Transit on POCUS Echocardiogram Not something you ever want to see! How much should clot
Clot in Transit ... should clot in transit ... s4c #cardiology #thrombus ... #VTE #pulmonaryembolism ... #AcutePE
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 Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation ... malignancy (Especially acute ... • Increased thrombin ... is simultaneous coagulation ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... coagulation factors ... drugs e.g. direct thrombin ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
affected in the intrinsic ... drugs (e.g. direct thrombin ... #differential #hematology ... #coagulation
Pulmonary Artery Clot seen on PSAX in Acute Saddle Pulmonary Embolism - Labeled Thrombus in Purple Suspicious
seen on PSAX in Acute ... Embolism - Labeled Thrombus ... for RV dilation, McConnell's ... The actual thrombus ... #Saddle #PulmonaryEmbolism
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... • Warfarin • Acute ... Liver disease • Acute ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology
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