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Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
of Tumor Lysis Syndrome ... Uric acid ≥ 8.0 mg ... Phosphorus ≥ 4.6 mg ... ≤ 7.0 mg/dL Clinical ... #TumorLysis #Syndrome
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Uric acid ≥ 8 mg ... /dL • Potassium ... ≤ 7 mg/dL • OR ... #Tumor #Lysis #Syndrome
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
- calcium > 11 mg ... /dL / >1 mg/dL the ... disease - Cr >2 mg ... /dL or CC < 40 ml ... plasmacytoma, POEMs syndrome
Gestational Hypertension & Preeclampsia Gestational Hypertension (gHTN) • BP > 140/90 • Onset > 20 wks gestation
Proteinuria (300 mg ... ) • Cr > 1.1 mg ... /dL or 2x • Thrombocytopenia ... Seizure HELLP Syndrome
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Bilirubin: <5 mg ... /dL • Hepatic ... necrosis HELLP Syndrome ... Bilirubin: <5 mg ... /dL unless massive
Albuminuria (Grades) and Risk for CKD Normal to mildly increased albuminuria: - Albumin excretion rate: < 30
excretion rate: < 30 mg ... excretion rate: 30-300 mg ... ratio: 30-300 mg ... hypoalbuminemia (<3.0 g/dL ... defined as nephrotic syndrome
Compelling and Possible Contraindications to Antihypertensive Drugs Diuretics (thiazides) - Gout - Metabolic syndrome, Glucose intolerance, Pregnancy,
- Metabolic syndrome ... creatinine >2.5 mg ... /dl„ in men, >2.0 ... mg/dL in women) ... - Metabolic syndrome
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hyperbilirubinemia syndrome ... than 20 to 50 mg ... /dL. ... ranging from 7-20 mg ... /dL • CN syndrome
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... uric acid > 10 mg ... /dl, treat with ... #Tumor #Lysis #Syndrome
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Hepatorenal Syndrome ... Creatinine by 0.3 mg ... /dL (27 μmol/L) ... #Hepatorenal #Syndrome
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