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diagnosis differential rheumatology management dementia hepatology lupus signs sle systemic vasculitis aids algorithm alkaline alp alzheimersdisease associated barre cerebritis classification
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #SLE #CNS #neurology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Fits, Hemiplegia, Ataxia ... Demyelinating syndromes ... Glomerulonephritis Myositis(5%) Blood ... SLE #systemic #erythematosus ... #signs #symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
mutations - Down syndrome ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Systemic Lupus Erythematosus ... (bulbar symptoms ... - opsoclonus-myoclonus ... Differential #Diagnosis #Causes ... #Neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Etiology: • Pathophysiology ... Neurological symptoms ... elevated white blood ... the underlying cause
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
often- Sensory ataxia ... Non-compressive Spinal Cord Causes ... Blockage of the Blood ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... pulses, bruis, or blood ... Large Vessel: Blood
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... • Depressive symptoms ... The clinical syndrome ... motor slowing and ataxia ... dementia #AIDS #Neurology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
deficiency • blood ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... normal CSF white blood ... than one after symptom ... the underlying pathophysiology ... diagnosis #management #neurology
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