1107 results
Esophageal Necrosis
Etiology:
 - Ischemia and Gastric Outlet Obstruction with GERD may be inciting events
 - Associated
Esophageal Necrosis ... Necrosis should ... melena - Other GI symptoms ... resolution of necrosis ... #Esophageal #Necrosis
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
Avascular Necrosis ... cells => Avascular Necrosis ... Sclerosis surrounding necrotic ... diagnosis #signs #symptoms
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Perivascular, Capillary necrosis ... Findings: Muscle necrosis ... Pathophysiology #Signs #Symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
(90%): Aseptic necrosis ... erythematosus #signs #symptoms
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Symptoms ... reactivity (Skin necrosis ... ulcers • Skin necrosis ... Warfarin-induced skin necrosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold-Induced Circulatory Symptoms ... (Cold-induced symptoms ... • Cutaneous necrosis ... Hemoglobinuria • Symptoms ... rewarming • Symptoms
Beta-Blocker Overdose/toxicity:

•	Bradycardia & hypotension (most common).
•	Myocardial depression & cardiogenic shock (severe overdoses). 
•	Ventricular dysrhythmias (Common with
Nearly all develop symptoms ... toxic epidermal necrolysis
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Statin-Associated Muscle Symptoms ... onset of muscle symptoms ... Myalgia/Myopathy Symptoms ... infiltrate engulfing necrotic ... Muscle biopsy if symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
- Palpable or necrotic ... Diagnosis #Signs #Symptoms
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
post-ingestion) - Symptom ... acute hepatic necrosis