10 results
diagnosis differential pharmacology algorithm causes high hypokalemia management renal table binder binders binding comparison diuresis diuretics dpp4 druginduced endocrinology excretion
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Poorly controlled DM ... reactions Common Drugs ... (Uncontrolled diabetes ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Poorly controlled DM ... reactions Common Drugs ... (Uncontrolled diabetes ... Medications 2. ... #high #nephrology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... and sodium • Dosing ... and calcium • Dosing ... of aspiration #Potassium ... #medications #pharmacology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Hyperkalemia ... Increased EC shift of K ... #pharmacology #potassium ... #medications #druginduced
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Hypokalemia - Differential ... Thyrotoxicosis Medications ... vomiting) • Low K ... Diagnosis #Algorithm #nephrology ... #low #potassium
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
Binder INDICATION ... oral suspension DOSING ... needed, based on K ... from other oral drugs ... with CKD, HF, or diabetes
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... different than other medications ... very tolerable medication ... Pharmacology #Management #Diabetes ... #DM2 #Endocrinology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... transfusions), ↓insulin (DM ... STOP offending medications ... Management #Treatment #potassium ... #nephrology #K
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Inhibitors of Na+K+ ... Hyponatremia • Hypercalcemia ... • Nephrogenic diabetes ... Excretion #Diuresis #Nephrology ... #Pharmacology #Medications
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
algorithm for hypokalemia ... Tubulopathy: urine K/ ... correcting serum potassium ... Other medications ... differential #algorithm #nephrology
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