21 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... algorithm Decreased ... renal potassium ... excretion • Acute ... #nephrology #potassium
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Diagnosis Algorithm ... Extra-renal Losses ... Bartter syndrome, Gitelman ... #causes #potassium ... #low #nephrology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... distal component of Nephron ... hyporenin hypoaldo, hyperkalemic ... immune reaction • Acute ... KidneyDisease #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... delivery to distal nephron ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... • Renal tubular ... Bartter's syndrome, Gitelman's ... #causes #nephrology ... #potassium
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... treated with IV potassium ... suggests extra-renal ... Bartter syndrome, Gitelman ... #nephrology #low
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... Losses Non-renal ... #nephrology #low ... #potassium
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
failure (acute ... Renal acidosis ... Generalized distal nephron ... Potassium-sparing ... diagnosis #causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
(renal potassium ... Sjögren syndrome, Renal ... Supplement: • Potassium ... Syndrome #diagnosis #nephrology ... #management #pathophysiology