21 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Pathophysiology of hypotonic hyponatremia

by Helbert Rondon, MD @NephroMD

#hypotonic #hyponatremia #nephrology #algorithm #Pathophysiology
Pathophysiology ... of hypotonic hyponatremia ... Helbert Rondon, MD @NephroMD ... #nephrology #algorithm ... #Pathophysiology
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Hypernatremia Diagnosis ... - fevers • renal ... volume loss - diuretics ... Diagnosis #Workup #Algorithm ... #Nephrology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... distal component of Nephron ... absorption in distal nephron ... : Hyponatremia ... KidneyDisease #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Differential Diagnosis Algorithm ... losses, Diuretic ... Ketonuria, Osmotic diuresis ... #Causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup Algorithm ... mOsm/kg - Implies renal ... , Ingestion Renal ... • Hypovolemic: Diuretics ... #nephrology #sodium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #nephrology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... • Increased renal ... activities • Diuretic ... syndrome #Mechanisms #pathophysiology ... #nephrology
Hyponatremia Diagnosis Algorithm
UOsm ≥ POsm - Vasopressin-Dependent
 • UNa < 20 mEq/L - Appropriate (↓ EABV)
Hyponatremia Diagnosis ... Algorithm UOsm ... solute intake, Renal ... Helbert Rondon, MD @NephroMD ... #causes #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Extra-renal Losses ... loss (Diarrhea) Renal ... Loop and thiazide diuretics ... Bartter syndrome, Gitelman ... potassium #low #nephrology