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differential algorithm lfts injury transaminitis aki alkaline cholangitis elevation hematology interpretation phosphatase primary rheumatology summary syndrome treatment activation acute acutekidneyinjury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Cholestasis / Obstructive ... - elevation Obstruction ... Cardiac muscle, Kidneys ... #chemistry #diagnosis ... #differential #Hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... skeletal muscle, kidney ... Bili - Direct (Obstructive ... Transaminitis #diagnosis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular Causes ... Intrahepatic - Obstruction ... #differential #diagnosis ... #algorithm #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... skeletal muscle and kidney ... Transaminitis #diagnosis ... #differential #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
aminotransferase (ALT ... Alkaline phosphatase (AlkP ... DBili) - Biliary obstruction ... Interpretation #diagnosis ... #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Highest • Bone • Liver ... Intestine - Other causes ... Intestine • Kidney ... #Algorithm #hepatology
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... tubular necrosis (causes ... Classification #diagnosis ... #nephrology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
• Caused by splanchnic ... Diagnosis (Clinical ... evaluation essential in all ... Hepatorenal #Syndrome #Hepatology ... #Nephrology #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... ) Differential Diagnosis ... Pregnancy #hepatology ... obstetrics #obgyn #diagnosis ... #management #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ... or higher • Liver ... #workup #hepatology
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