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diagnosis endocrinology pathophysiology algorithm differential causes msk pituitary acromegaly management signs symptoms clinical fracture growthhormone joint orthopedics radiology rankl treatment
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... IGFIR activates osteoblasts ... /Symptoms: • GH ... abn lipid • GH ... #FeedbackLoop #
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
relationship between osteoblasts ... marrow cells and osteoblasts ... RANK stimulates osteoclast ... projections from an osteoclast ... lysosomes in the osteoclast
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
enlargement - If GH ... • GH stimulates ... adenomas are mixed GH ... level (↑Sens) - GH ... (Lanreotide) ± GH
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... GrowthHormone #GH
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Prolactin #PRL #FeedbackLoop
Acromegaly Caused by over-secretion of growth hormone (GH) from the pituitary gland. The condition is rare
growth hormone (GH
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts
Rheumatoid Arthritis Rheumatoid Arthritis (RA) is an inflammatory autoimmune condition. While chiefly thought of as a joint
TNF #CRP #RANKL #ostoblast
Sellar / Pituitary Mass - Differential Diagnosis Algorithm Adenoma - Primary Anterior Pituitary - Secreting
Prolactin • GH
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Cushing's Disease • GH
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