323 results
diagnosis management cardiology differential algorithm clinical ekg ecg electrocardiogram pathophysiology causes treatment checklist pharmacology criticalcare nephrology pediatrics classification neurology peds
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with PR3 ... involvement - PR3 ... 75-90%, rarely PR3 ... disease - MPO>PR3 ... + almost 100%, PR3
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO>PR3 ... polyangiitis - PR3 ... involvement - PR3 ... Churg-Strauss) - MPO>PR3 ... disease - MPO>PR3
The Cell Cycle The cell cycle is the series of tightly regulated steps that controls cell growth
in the case of p53 ... Thats right, p53 ... is too great, p53 ... Yes, its p53 (and ... #cell #cycle #p53
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinase 3 (PR3 ... in >90%, MPO > PR3 ... Granulomas - MPO > PR3 ... 80% (80-90% have PR3 ... proteinase 3 (PR3
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
Vasculitis • GPA - PR3 ... negative • MPA - PR3 ... negative • EGPA - PR3 ... positivity for MPO and PR3 ... sensitivity #MPO #PR3
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
(MPO) C-ANCA (PR3
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3
Causes of Hypercalcemia due to increased Vitamin D levels • The BIG 3:
granulomatous diseases: PR3
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinase 3 (PR3 ... in > 30 / MPO > PR3 ... hemoptysis, MPO > PR3 ... 90 percent have PR3
External Ventricular Drains (EVDs) & ICP waveform interpretation An EVD is a temporary closed sterile system that
compliance) • P3 ... with P1 > P2, P3 ... with P2 > P1, P3
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