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diagnosis differential management algorithm anemia neurology rheumatology coagulation oncology barre bleeding bruising disorders elevatedmcv guillain intravascular macrocytosis mds myelodysplastic prolonged
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... Study #diagnosis #hematology ... pathophysiology #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Jcortesizaguirr #Abnormal ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Causes include : ... amyloidosis #Abnormal ... #differential #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Toxic Damage (e.g ... Non-lmmune: • HELLP Syndrome ... Diagnosis #Algorithm #Causes ... #Hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... mild cases) • ... hemophilia type (e.g ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... Deficiency - Abnormal ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Secondary (e.g ... Anemias (MAHA) - Abnormal ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... macrosomia) • Bladder distension ... succenturiate lobe • Abnormal ... TTP) • HELLP syndrome ... Diagnosis #Algorithm #Causes
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Variant, Normal ... 21 • Noonan Syndrome ... • Turner Syndrome ... Panhypopituitarism Treatment ... endocrinology #causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... Extravascular #Causes ... differential #diagnosis #hematology
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