54 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... 3) Loop Diuretics ... spironolactone) #Pathophysiology ... #Nephrology #Nephron ... #Diuretics #Hormones
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... receptor antagonists (also ... as no effect on ... #Pharmacology #nephrology ... loop #thiazide #classes
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Symport (Loop Diuretics ... Kidney stones caused ... Postoperative abdominal distention ... #Nephrology #Pharmacology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... polyneuropathy (e.g ... injury, Early ALS ... Eclampsia, Late ALS ... diagnosis #table #neurology
Causes of Polyuria - Differential Diagnosis
Excess Intake of Water:
 • Primary polydipsia (a.k.a. "psychogenic polydipsia")
 •
Causes of Polyuria ... a.k.a. osmotic diuresis ... : Conventional diuretics ... SGLT2 inhibitors (e.g ... #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Defining the cause ... Clinicians should also ... Post-hypercapnia • Diuretics ... #nephrology #potassium
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Thiazide or loop diuretics ... after renal tubule diuretic ... Differential #Diagnosis #Causes ... #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... syndrome • Triggers: Diuretics ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... administration • Osmotic diuresis ... Polyuria scheme) e.g ... Hypernatremia #Nephrology ... Diagnosis #Algorithm #Causes