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diagnosis differential rheumatology vasculitis dermatology causes cryofibrinogenemia cryoglobulins description enzymes gammopathy glomerulonephritis hepatology lfts liver mgrs monoclonal morphology progressive rapidly
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... Classification ... phenomenon, Digital ulcers ... #Classification ... #Types #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... Purpura - Skin ulcers ... Types: • Type ... #classification ... #rheumatology #
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... Differential Diagnosis Algorithm ... • Bleomycin Hematologic ... Thalessemia • Cryoglobulinemia ... Viral - Herpes simplex
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cooled from the normal ... Divided Into Two Types ... sensitivity • Painful ulcers ... Calciphylaxis • Cryoglobulinemia ... #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
immunofluorescence Immune Complex ... Lupus Nephritis, Cryoglobulinemia ... Idiopathic • Normal ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... ANCA +MPO) • Cryoglobulinemic ... livedo reticularis, ulcers ... genital aphthous ulcers ... #classification
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... definitive outcomes for users ... disease; T2DM, type ... #Algorithm #Hepatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
livedo reticularis, ulcers ... fluid (CSF) is abnormal ... pauci-immune GN Immune Complex ... / ANCA + MPO) Cryoglobulinemic ... genital aphthous ulcers
Morphology of Secondary Skin Lesions - Description Algorithm Secondary Skin Lesion - Lesion that develops from trauma,
- Description Algorithm ... accentuation of normal ... of injury) • Ulcer ... (complete loss ... #dermatology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
meet criteria for hematologic ... kidney function • Abnormal ... guide subtype classification ... vasculitis Types ... immunotactoid GN, cryoglobulinemic
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