76 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies (ANA ... used to detect ANAs ... Positive ANA ≠ Autoimmune ... The higher the ANA ... often not specific ANA
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... erythematosus (SLE ... erythematosus (SLE ... Antinuclear #Antibodies #ANA
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Antinuclear antibody (ANA ... have ANAs; thus ... , a negative ANA ... B serology • ANAs ... CRP level • ANAs
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... searched for when ANA ... Association with both SLE ... higly specific for SLE ... rheumatology #table #ANA
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Disease Associations ANA ... Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Diffuse) Anti-Sm - SLE
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Workup: - ANA ... Workup: - ANA ... management of SLE ... druginduced #lupus #sle
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
Link to chronic paracetamol ... • Continuous paracetamol ... Diagnosis: • HAGMA; Paracetamol ... turnaround) • le ... HDU • Withdraw paracetamol
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... dysmotility • MCTD (SLE ... • Specific for SLE ... Ann Marie Kumfer ... Erythematosus #SLE
Lower GI Bleed - Differential Diagnosis Algorithm

 • Structural: Diverticulosis, Hemorrhoids, Post-polypectomy, Polyps & malignancy, Anal
Differential Diagnosis Algorithm ... & malignancy, Anal ... fistula, Colonic and ... Differential #Diagnosis #Algorithm
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... ) - Diagnosis and ... are evocative of SLE ... Workup: - ANA ... management of SLE