9 results
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Aplastic Anemia ... Pathophysiology • DDx ... Expectation • Rx Algorithm ... #Aplastic #Anemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... MAHA: TTP, HUS, DIC ... incompatibility • Paroxysmal ... #Hemolytic #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... → Sickle Cell anemia ... (TTP, HUS, DIC, ... Differential #Diagnosis #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... intravascular coagulation (DIC ... Transfusion reaction, Paroxysmal ... diagnosis #hematology #anemia
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... • TTP/HUS • DIC ... Differential #Diagnosis #Algorithm
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... and thymoma DDX ... marrow-failure syndromes • Paroxysmal
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... thrombocytopenia - DIC ... ARUPLabs #Hemolytic #Anemia ... Differential #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... immune-complex hemolytic anemia ... • MAHA (TTP, DIC ... Differential #Diagnosis #Algorithm
Evaluation of Recurrent Falls

Core Concept:
Maintaining an upright posture requires the integrated function of multiple systems.
Disruption in
embolism - Severe anemia ... : - Benign paroxysmal ... positional vertigo (BPPV