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algorithm management causes oncology workup hemolytic chronic cll eosinophilia eosinophils hemolysis hypereosinophilia leukemia lymphocytic pancytopenia rheumatology thrombocytosis acquired agglutinin bandemia
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
• Clinically ... Relevant HES Variants ... disorders • Diagnosis ... and Treatment Algorithm ... #HES #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... - Diagnosis and ... thrombocythemia), Autoimmune ... #treatment #hematology ... #differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Diagnosis Algorithm ... Consumption Disorders ... Autoimmune Mediated ... Acquired Aplastic Anemia ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Chronic inflammatory disorders ... (e.g. autoimmune ... Myelodysplastic syndrome ... #hematology #secondary
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... #Diagnosis #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Diagnosis Algorithm ... Consumption Disorders ... Autoimmune Mediated ... Acquired Aplastic Anemia ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Diagnosis Algorithm ... Normal Blood Smear ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... (HUS) • Other ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
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