14 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... (>1000): • DILI ... #Function #Tests ... #LFTs #Differential ... #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... abnormality vs bone Bili ... #FunctionTest #LFTs ... Transaminitis #diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Diagnosis Algorithm DILI ... non-essential drug/HDS treatments ... disease, Hepatic ... Diagnosis #Algorithm #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... #Function #Tests ... #LFTs #Laboratory ... Interpretation #diagnosis #hepatology
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... - Vitals - LFTs ... GTT, indirect bili ... disease work up ... Calling #Referral #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... months without treatment ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
test abnormalities ... Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... Differential #Diagnosis #hepatology ... Transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... • Iatrogenic: DILI ... extrahepatic source - Tests ... Unconjugated Bili ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... of cholestatic disease ... disease: > 2 ... #differential #Hepatology ... transaminitis #LFTs