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management differential leukemia algorithm causes chronic classification cll lymphocytic mds myelodysplastic workup approach cell electrophoresis hematololgy hemeonc hemolytic hodgkins indications
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... #Anemia #diagnosis ... #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Normochromic RBCs on Smear ... Deficiency • Aplastic ... Spherocytes on Smear ... Algorithm #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic anemia ... and laboratory diagnosis ... arrow) Peripheral smear ... #Hematology #Pathology ... #Smear #Microscopy
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... • Peripheral smear ... 5) Symptoms of anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Peripheral smear ... • Neutropenia, anemia ... Pure red cell aplasia ... #workup #oncology ... #hematology
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
• New-onset anemia ... peripheral blood smear ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology ... #Diagnosis
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