22 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... ongoing ↑ LFTs or symptoms ... Calculate R-Value • Hepatocellular ... #differential # ... gastroenterology #hepatology
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #Injury #Pathophysiology ... #hepatology
Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... Injury #Medications ... #Differential # ... #LiverInjury #Hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Injury Hepatocellular ... Liver Injury ... Transaminitis #diagnosis #differential ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... involvement, Kidney injury ... alternative causes • Hepatocellular ... #Injury #Diagnosis ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Acute Liver Injury ... #differential # ... diagnosis #algorithm #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
abnormality vs bone Bili ... Indirect (Hemolytic) Hepatocellular ... ALP) ≥5: Hepatocellular ... injury >2 ... 2: Cholestatic injury
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injuryliver ... Liver Injury Differential ... #Liver #Injury
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - Differential ... (>1000): • DILI ... injury) • Ischemic ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
ALP) • R > 5: Hepatocellular ... Cellular Destruction: Hepatocellular ... ALP: Typical of hepatocellular ... chemistry #diagnosis #differential ... #Hepatology #transaminitis