11 results
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... Diagnosis #Algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
pylori test (GI symptoms ... changes), high MCV ... anemia (vegan, ... gastric bypass), LFT ... Causes #Workup #hematology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... Infection (EBV/CMV ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... or symptoms of ... Idiosyncratic #differential ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
- Differential ... /B/C/D/E, EBV, CMV ... #Differential # ... Diagnosis #hepatology ... Transaminitis #LFTs
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Marrow (Toxic injury ... - EBV - CMV ... - HCV - HIV ... • Improve the symptoms ... #oncology #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... hepatitis serologies, HCV ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• Pernicious anemia ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic ... Hyophosphatasia #hepatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
to local skin injury ... ) • Neurologic ... CNS symptoms (headache ... Behcet disease) Differential ... #rheumatology #
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential