11 results
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin Reuptake Inhibitors ... SSRIs #Serotonin #Inhibitors ... #Pathophysiology ... #Pharmacology # ... Diagnosis #Signs #Symptoms
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
inducers (↑) and inhibitors ... by inducers or inhibitors ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine Reuptake Inhibitors ... SerotoninNorepinephrine #Inhibitors ... #Pathophysiology ... #Pharmacology # ... Diagnosis #Signs #Symptoms
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Immune Checkpoint Inhibitor ... Incidence, Symptoms ... #SideEffects #Table ... #Diagnosis #Pharmacology ... #Oncology
Drugs for Depression and Anxiety Disorders

Selective Serotonin Reuptake Inhibitors
 • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline,
Serotonin Reuptake Inhibitors ... PTSD, menopause symptoms ... • Inhibitors ... #Medications #Table ... #Pharmacology #
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Constitutional symptoms ... (Bruton kinase inhibitor ... Venetoclax (BCL2 inhibitor ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... ARDS to explain symptoms ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology ... diagnosis #comparison #table
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... diagnosis #management #hematology ... #oncology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
pyrophosphate: Inhibitor ... collection with EDTA Pathophysiology ... mineralization Symptoms ... Hyophosphatasia #hepatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... methyltransferase inhibitors ... Syndromes #diagnosis #hematology ... #oncology