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diagnosis differential lymphadenopathy management diffuse focal localized allergy ana anca antibodies antibody antineutrophil cerebritis classification cns diseases erythematosus leukemia leukostasis
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Reactive: - Systemic ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... antibodies) • Systemic ... • Sjögren syndrome ... Anti-La/SSB • ... antibodies #diagnosis #rheumatology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... CNS #neurology #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... high WBC count cause ... : • Pathophysiology ... diagnosis #management #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... Autoantibodies: • WAIHA • CAD ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... Central nervous system ... Nephrogenic DI Hematologic ... #Rheumatology #
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
into a 4-pass system ... • CKD/ESRD & CAD ... cell activation syndrome ... Mastocytosis • Other hematologic ... Differential #Diagnosis #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... an underlying cause ... frequently affected systems ... Better call hematology ... #workup #hematology
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