21 results
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Cyanide Toxicity ... Amyl nitrite - causes ... #Cyanide #Toxicity ... #Toxicology #Pathophysiology ... #Management #Treatment
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... LacticAcidosis #Toxicity ... Toxicology #Diagnosis #Management
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... no respiratory cause ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... Abdominal pain, nausea ... deterioration Shock and metabolic ... - Anion gap metabolic ... Toxicology #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... = nonspecific (nausea ... #pathophysiology
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
step in purine metabolism ... Homeostasis #Gout #Pathophysiology ... #Pharmacology # ... Medications #Management
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... intracellular calcium causes ... effect of digoxin toxicity ... #Pathophysiology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
following first-pass metabolism ... - Metabolism - ... Clozapine is known to cause ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
it should not cause ... glycol (solvent) toxicity ... Versed) - CYP3A4 metabolism ... No pharmacologic ... CriticalCare #diagnosis #management
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Diagnosis and Management ... , Heat stroke, Metabolic ... Dermatomyositis) AKI - Pathophysiology ... Differential #Diagnosis #Management ... #Summary #causes