26 results
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... of carbohydrate metabolism ... state and fat metabolism ... #Pathophysiology ... DKA #Diabetes #Endocrinology
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... (DKA) - caused ... (pH < 7.35) w/ elevated ... differential #diagnosis #management ... #endocrinology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic Ketoacidosis ... Definition of EuDKA • Metabolic ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management ... #endocrinology
Diabetic Ketoacidosis (DKA) - Diagnosis and Management Summary

Symptoms:
• Abdominal pain
• Nausea
• Polyuria
• Polydipsia
• Vomiting
• Weight loss
•
Diabetic Ketoacidosis ... Diagnosis and Management ... Abdominal pain • Nausea ... #Diagnosis #Management ... #Endocrinology
Diabetic Ketoacidosis (DKA) - Diagnosis and Management Summary

Symptoms:
• Abdominal pain
• Nausea
• Polyuria
• Polydipsia
• Vomiting
• Weight loss
•
Diabetic Ketoacidosis ... Diagnosis and Management ... Abdominal pain • Nausea ... #Diagnosis #Management ... #Endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... out of cells may cause ... falsely normal/elevated ... Due to neuronal metabolism ... #endocrinology
Causes of Metabolic Acidosis with Elevated Anion Gap - Differential Diagnosis Algorithm
Elevated Anion Gap > 12
Causes of Metabolic ... Acidosis with Elevated ... Diagnosis Algorithm Elevated ... Ketosis • Diabetic ketoacidosis ... Diagnosis #Algorithm #Causes
Hyperglycemic Crisis - Algorithm for DKA/HHS

Diagnostic criteria for DKA:
 • pH < 7.3
 • Anion gap
• Serum BHB elevated ... Crisis #Algorithm #management ... #endocrinology ... Diabetes #DM2 #Ketoacidosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Diagnosis and Management ... no respiratory cause ... show anion-gap metabolic ... , Tachycardia, Elevated ... Labs: Anion-Gap Metabolic
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Causes of Hypercalcemia ... hypercalcemia Vitamin D metabolic ... • Sarcoidosis (elevated ... Hypercalcemia #Causes ... #endocrinology