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diagnosis causes management syndrome growthhormone pituitary signs acromegaly apml differentiation druginduced encephalopathy excess feedbackloop fever glftap hematology hyperthyroidism macroadenoma masseffects
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... lipolysis Signs/Symptoms ... abn lipid • GH ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
malignancy Pathophysiology ... • GH stimulates ... Differential Diagnosis ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Drug-Induced Edema Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
Drug-Induced Edema ... Drug-induced edema ... Medication #Causes #Differential ... #Pharmacology # ... Pathophysiology
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework High Altitude Pulmonary Edema: • Accumulation
(NCPE) - Differential ... 10,000 ft) • Symptoms ... • Signs/Symptoms ... • Signs/Symptoms ... #causes #differential
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
, peri orbital edema ... causes #diagnosis #differential ... #endocrinology ... #signs #symptoms
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
matter vasogenic edema ... Etiology: • Pathophysiology ... Neurological symptoms ... • Vasogenic edema ... Reversible course Differential
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... myalgias, HoTN, edema ... Diagnosis: >3 symptoms ... initiation • Differential
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis EPIDEMIOLOGY: PFAPA is the most common syndrome entailing
fever (FMF) PATHOPHYSIOLOGY ... reporting such symptoms ... several other symptoms ... DIFFERENTIAL DIAGNOSIS ... abdominal pain, and edema
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