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management symptoms erythematosus neurology sle systemic hematology behcet cerebritis cns differential disease gout gravis hemeonc hemophagocytic hlh leukostasis lymphohistiocytosis lysis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
s Syndrome: Pathogenesis ... RA) or systemic lupus ... erythematosus (SLE) Signs ... #Syndrome #Pathophysiology ... #Diagnosis #Signs
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... heart block • Sjogren ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
loss (50%) Eye: Sjögrens ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... permeability Diagnosis ... CNS #neurology #rheumatology ... #cerebritis #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... : • Pathophysiology ... #TLS #diagnosis ... #management #hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Autoimmune: thyroid, Sjogren ... myasthenia Diagnosis ... test - Cogan sign ... - Peek sign ... Myasthenia #Gravis #diagnosis
Optic Neuritis - Diagnosis and Management • Epidemiology: Female (75%), 18-50 years, caucasian • Symptoms: Moderate visual
Optic Neuritis - Diagnosis ... Unilateral • Signs ... - Typical MS-like ... #rheumatology # ... ophthalmology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... phenomenon (16%) MSK ... Adenocarcinoma Treatment ... #Syndrome #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
) Differential Diagnosis ... Arthritis, AS Treatment ... inhibitors • Uveitis- Ophthalmology ... #signs #symptoms ... #rheumatology #
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... survival is 93-95% Pathophysiology ... skin (16-32%): lupus ... anterior/posterior MSK ... #Management #Signs
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