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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
Interpretation of Components of the CBC (Complete Blood Count)

#CBC #Interpretation #CompleteBloodCount #Hematology #Differential #Diagnosis #Laboratory
Components of the CBC ... Blood Count) #CBC ... CompleteBloodCount #Hematology ... #Differential #
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Features of hematologic ... #Leukocytosis #Differential ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
Summary table of comparison of the difference between primary biliary cholangitis (PBC) and primary sclerosing cholangitis
biliary cholangitis (PBC ... sclerosing cholangitis (PSC ... #differential #hepatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Artifact (redo CBC ... Non malignant hematologic ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
pathophysiology #pbc ... #psc #hepatology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... Infiltration: • Hematologic ... and non-hematologic ... #Neutropenia #Differential ... Algorithm #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Lymphadenopathy - Differential ... (Pancytopenia, WBC ... differential includes ... Lymphocytic Leukemia (CBC ... Algorithm #Causes #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias - Differential ... • Extrinsic RBC ... • Intrinsic RBC ... Hemolytic #Anemias #Differential ... Diagnosis #Algorithm #hematology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Non-infectious (malignancy, rheumatologic ... Thrombocytosis #Differential ... causes #Platelets #hematology