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diagnosis differential lymphadenopathy antibodies diffuse diseases focal localized syndrome workup ana anca anemia antibody antineutrophil antinuclear associations autoantibodies classification dermatology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... Differential Diagnosis Algorithm ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
biliary cirrhosis (PBC ... Ro), Anti-SSB (La ... disease c-ANCA - Vasculitis ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
multiplex • Hematuria ... PR3-ANCA): • Microscopic ... tract, and often causes ... Tests: • CBC ... differential #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... nucleotidase deficiency, lead ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm ... #workup #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... , + lab signs of ... N/V, lethargy, hematuria ... diagnosis #management #hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-La/SSB • ... ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... • Mesenteric vasculitis ... non-nephrotic proteinuria, hematuria ... Erythematosus #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
+Organomegaly+↑RBC ... Autoimmunity: • -MM/WM: Vasculitis ... Autoantibodies: • WAIHA • CAD ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
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