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diagnosis differential causes algorithm hematology emesis oncology vomiting adverse adverseeffects aplastic atlas bear bloodcell calculation chronic classes deficiency ekg fatigue
Common sodium channel blockers which cause QRS widening. Anticonvulsants: - Carbamazepine Antidysrhythmics: - Group
Anticonvulsants: ... Antimalarial drugs ... Propranolol Chemotherapy ... QRS #widening #ECG ... #EKG #Pharmacology
Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues • Asparagine: neurotoxicity • Cisplatin:
Chemotherapy Toxicity ... Cumulatively Toxic Drugs ... Bear #Mnemonic #Drugs ... #pharmacology # ... oncology #SideEffects
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Chemotherapy) ... methotrexate) • Drugs ... anti-HLA antibodies Drugs
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Anticonvulsants ... cytotoxic reaction to drug ... thrombocytopenia #Anticonvulsants ... MoodStabilizers #Mechanism #SideEffects ... Pathophysiology #Psychiatry #Pharmacology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... infiltration (e.g ... Marrow suppression (e.g ... . drugs, chemotherapy ... Intrinsic RBC defects (e.g
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Disease, MDS, Chemotherapy ... (e.g. methotrexate ... disorders, Oxidative drugs
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Diet: ↓ Intake, e.g ... Gastritis, Surgery, Drugs ... Children, EPO / chemotherapy ... differential #diagnosis #anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... /Chemotherapy ... - NSAIDs - Anticonvulsants
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Hematologic • Anemia ... Myasthenia Gravis Pharmacologic ... Abuse (e.g. ... Alcohol) • Drug ... Malnutrition / Drug
Pediatric Vomiting - Gastrointestinal and Systemic Causes - Differential Diagnosis Algorithm Hepatobiliary: • Acute Hepatitis • Acute
Diabetes/ DKA • Uremia ... Other: • Sepsis (e.g ... Tract Infection Drugs ... /Toxins: • Chemotherapy
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