12 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Infiltration: • Hematologic ... and non-hematologic ... suppression: • Chemotherapy ... Radiation • Drugs ... Toxins • Aplastic Anemia
Common sodium channel blockers which cause QRS widening.

Anticonvulsants: 
 - Carbamazepine 
Antidysrhythmics:  
 - Group
Anticonvulsants: ... Antimalarial drugs ... Phenothiazines Drugs ... Propranolol Chemotherapy ... widening #ECG #EKG #Pharmacology
Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues
 • Asparagine: neurotoxicity
 • Cisplatin:
Chemotherapy Toxicity ... Cumulatively Toxic Drugs ... Bear #Mnemonic #Drugs ... #pharmacology # ... oncology #SideEffects
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Chemotherapy) ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Algorithm #Causes #Hematology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Anticonvulsants ... cytotoxic reaction to drug ... thrombocytopenia #Anticonvulsants ... MoodStabilizers #Mechanism #SideEffects ... Pathophysiology #Psychiatry #Pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... /Chemotherapy ... - NSAIDs - Anticonvulsants ... #oncology #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Disease, MDS, Chemotherapy ... disorders, Oxidative drugs ... differential #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... suppression (e.g. drugs ... , chemotherapy, ... Production #Index #hematology
Summary of the adverse effects associated with the use of trimethoprim–sulfamethoxazole

Mnemonic - NOT RISKY?

N - Neurologic
capacity and other hematologic ... Interactions with other drugs ... adverse #effects #SideEffects ... #Pharmacology #
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Myasthenia Gravis Pharmacologic ... Alcohol) • Drug ... Malnutrition / Drug