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hematology algorithm causes workup hemolytic comparison pancytopenia platelet rheumatology thrombocytosis agglutinin ana antibodies antinuclear atlas blood bloodcell cold disease diseases
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Diagnosis Algorithm ... Pelger-Huet, Macrocytic anemia ... #hematology #Markers ... #Differential #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... diverse genotypes): SS ... Consider RBC membrane disorder
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... /Quantity: • Primary ... - Hemolytic anemia ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgM) (e.g. primary ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Myelogenous Leukemia • Primary ... • Rheumatic disorders ... Iron deficiency anemia ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... Chronic inflammatory disorders ... Post-splenectomy Primary ... #hematology #secondary
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Diagnosis Algorithm ... Consumption Disorders ... Acquired Aplastic Anemia ... Primary hematological ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Diagnosis Algorithm ... Consumption Disorders ... Acquired Aplastic Anemia ... Primary hematological ... #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Unstable hemoglobin disorders ... RBC: Hemoglobin SS ... RBC #Morphology #differential ... #diagnosis #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... MYH9-Related Disorder ... #comparison #table ... #differential # ... diagnosis #hematology
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